J Haem Pract 2013; 1(1):J Haem Pract 2014; 1(1): 5-7. doi: 10.17225/jhp00003

Authors: Bert Leenders

Bert Leenders
Paediatric haemophilia nurse
Queen Fabiola Children’s University Hospital, Brussels, Belgium, Brussels, Avenue Crocq 15, 1020 Brussels, Belgium.


Haemophilia A is an X-linked congenital bleeding disorder resulting from a deficiency of factor VIII (FVIII). Therapy to prevent or treat bleeding is by replacement of the missing FVIII. However, as a consequence of treatment, patients with HA may develop inhibitory IgG antibodies to FVIII, termed “inhibitors”. When this occurs, treatment becomes more complex and costly and morbidity increases. Inhibitor formation, occurring in up to 36% of patients with severe HA, is currently one of the most significant complications affecting patients with HA. In these two case studies, the management of bleeds in patients with inhibitors, and the long-term inhibitor eradication will be discussed.


The author is a member of the EAHAD nurses committee and has served on advisory boards for Bayer and Novo Nordisk.


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